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Cardigos, J., Barcelos, F., Carvalho, H., Hipólito, D., Crisóstomo, S., Vaz-Patto, J....Alves, N. (2019). Tear meniscus and corneal sub-basal nerve plexus assessment in primary Sjögren syndrome and Sicca syndrome patients. Cornea. 38 (2), 221-228

J. Cardigos et al.,  "Tear meniscus and corneal sub-basal nerve plexus assessment in primary Sjögren syndrome and Sicca syndrome patients", in Cornea, vol. 38, no. 2, pp. 221-228, 2019

@article{cardigos2019_1714618819806,
	author = "Cardigos, J. and Barcelos, F. and Carvalho, H. and Hipólito, D. and Crisóstomo, S. and Vaz-Patto, J. and Alves, N.",
	title = "Tear meniscus and corneal sub-basal nerve plexus assessment in primary Sjögren syndrome and Sicca syndrome patients",
	journal = "Cornea",
	year = "2019",
	volume = "38",
	number = "2",
	doi = "10.1097/ICO.0000000000001800",
	pages = "221-228"
}

TY  - JOUR
TI  - Tear meniscus and corneal sub-basal nerve plexus assessment in primary Sjögren syndrome and Sicca syndrome patients
T2  - Cornea
VL  - 38
IS  - 2
AU  - Cardigos, J.
AU  - Barcelos, F.
AU  - Carvalho, H.
AU  - Hipólito, D.
AU  - Crisóstomo, S.
AU  - Vaz-Patto, J.
AU  - Alves, N.
PY  - 2019
SP  - 221-228
SN  - 0277-3740
DO  - 10.1097/ICO.0000000000001800
AB  - PURPOSE: To evaluate lower tear meniscus and corneal sub-basal nerve plexus in primary Sjögren's syndrome (pSS) and Sicca syndrome patients. METHODS: Cross-sectional study of 116 patients with Sicca syndrome associated with pSS and not associated with Sjögren's syndrome (non-SS Sicca) and 20 normal control subjects. Tear meniscus height and area were measured using anterior segment optical coherence tomography; corneal sub-basal nerve plexus density, length, and tortuosity were evaluated using in vivo confocal microscopy. Data analysis was performed using IBM-SPSS Statistics 24.0. RESULTS: Corneal sub-basal nerve plexus density and length were significantly lower, and tortuosity was significantly higher in pSS and non-SS Sicca groups than in normal control subjects (P < 0.001; P = 0.018, respectively). Corneal sub-basal nerve plexus presented a strong association with Schirmer test I and tear breakup time. Cutoff values of sub-basal nerve plexus density (36.5 nerve/mm) and length (12.5 mm/mm) presented 80.2% to 81.9% sensitivity and 85% specificity for detecting Sicca syndrome patients. No significant differences were found between the 3 groups regarding tear meniscus height and area. CONCLUSIONS: Corneal sub-basal nerve plexus in vivo confocal microscopy may be a useful tool in the assessment of dry eye disease in Sicca syndrome, complementing the information provided by the conventional modalities used in dry eye disease evaluation.
ER  -