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Simões, B., Vassos, E., Shergill, S., McDonald, C., Toulopoulou, T., Kalidindi, S....Prata, D. (2020). Schizophrenia polygenic risk score influence on white matter microstructure. Journal of Psychiatric Research. 121, 62-67

B. Simões et al.,  "Schizophrenia polygenic risk score influence on white matter microstructure", in Journal of Psychiatric Research, vol. 121, pp. 62-67, 2020

@article{simões2020_1716212130661,
	author = "Simões, B. and Vassos, E. and Shergill, S. and McDonald, C. and Toulopoulou, T. and Kalidindi, S. and Kane, F. and Murray, R. and Bramon, E. and Ferreira, H. and Prata, D.",
	title = "Schizophrenia polygenic risk score influence on white matter microstructure",
	journal = "Journal of Psychiatric Research",
	year = "2020",
	volume = "121",
	number = "",
	doi = "10.1016/j.jpsychires.2019.11.011",
	pages = "62-67",
	url = "http://www.journals.elsevier.com/journal-of-psychiatric-research/"
}

TY  - JOUR
TI  - Schizophrenia polygenic risk score influence on white matter microstructure
T2  - Journal of Psychiatric Research
VL  - 121
AU  - Simões, B.
AU  - Vassos, E.
AU  - Shergill, S.
AU  - McDonald, C.
AU  - Toulopoulou, T.
AU  - Kalidindi, S.
AU  - Kane, F.
AU  - Murray, R.
AU  - Bramon, E.
AU  - Ferreira, H.
AU  - Prata, D.
PY  - 2020
SP  - 62-67
SN  - 0022-3956
DO  - 10.1016/j.jpsychires.2019.11.011
UR  - http://www.journals.elsevier.com/journal-of-psychiatric-research/
AB  - Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations, should be assessed on heritable brain phenotypes also previously associated with the illnesses, for a better understanding of the pathways to disease. We have recently reported on the current SZ PRS's ability to predict 1st episode of psychosis case-control status and general cognition. Herein, we test its penetrance on white matter microstructure, which is known to be impaired in SZ, in BD and their relatives, using 141 participants (including SZ, BP, relatives of SZ or BP patients, and healthy volunteers), and two white matter integrity indexes: fractional anisotropy (FA) and mean diffusivity (MD). No significant correlation between the SZ PRS and FA or MD was found, thus it remains unclear whether white matter changes are primarily associated with SZ genetic risk profiles.
ER  -