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Teodoro, M. F., Andrade, M. A. P. & Oliveira, T. A. (2024). Evaluating the bioequivalence of treatments using t-ratios tests. In ICoMS '24: Proceedings of the 2024 7th International Conference on Mathematics and Statistics. (pp. 102-106). Amarante Portugal: ACM - Association for Computing Machinery.
M. F. Teodoro et al., "Evaluating the bioequivalence of treatments using t-ratios tests", in ICoMS '24: Proc. of the 2024 7th Int. Conf. on Mathematics and Statistics, Amarante Portugal, ACM - Association for Computing Machinery, 2024, pp. 102-106
@inproceedings{teodoro2024_1782698163322,
author = "Teodoro, M. F. and Andrade, M. A. P. and Oliveira, T. A.",
title = "Evaluating the bioequivalence of treatments using t-ratios tests",
booktitle = "ICoMS '24: Proceedings of the 2024 7th International Conference on Mathematics and Statistics",
year = "2024",
editor = "",
volume = "",
number = "",
series = "",
doi = "10.1145/3686592.3686610",
pages = "102-106",
publisher = "ACM - Association for Computing Machinery",
address = "Amarante Portugal",
organization = "",
url = "https://dl.acm.org/doi/10.1145/3686592.3686610"
}
TY - CPAPER TI - Evaluating the bioequivalence of treatments using t-ratios tests T2 - ICoMS '24: Proceedings of the 2024 7th International Conference on Mathematics and Statistics AU - Teodoro, M. F. AU - Andrade, M. A. P. AU - Oliveira, T. A. PY - 2024 SP - 102-106 DO - 10.1145/3686592.3686610 CY - Amarante Portugal UR - https://dl.acm.org/doi/10.1145/3686592.3686610 AB - The main objective of the work is the application of experimental design and some simple tests (t-ratios) in the evaluation of bioequivalence of two treatments. It is performed the assessment of the effectiveness of different treatments administered to two groups of patients: the control group and the test group. The comparison of the control group that received the reference medication with the control group test, which received the drug under study, using a crossover experimental design. It was performed an analysis using t-ratios and considering and inter-subject variability formulation of the probabilistic model, where the specification of tests for detection of carryover and period effects were considered. The application to a practical case consisted in the validation of the hypothesis of the proposed model took place, where the effects carryover and period were not significant when considering usual levels of significance. About the treatments, we could conclude that there was statistical significance to affirm that the studied pharmaceuticals were not bioequivalent. ER -
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