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M. Filomena Teodoro, Andrade, M. A. P. & Teresa A. Oliveira (2024). Evaluating the Bioequivalence of Treatments Using t-ratios Tests. 7th International Conference on Mathematics and Statistics,.
M. F. Teodoro et al., "Evaluating the Bioequivalence of Treatments Using t-ratios Tests", in 7th Int. Conf. on Mathematics and Statistics, Amarante, Portugal, 2024
@misc{teodoro2024_1791950878143,
author = "M. Filomena Teodoro and Andrade, M. A. P. and Teresa A. Oliveira",
title = "Evaluating the Bioequivalence of Treatments Using t-ratios Tests",
year = "2024",
howpublished = "Both (printed and digital)",
url = "https://www.icoms.org/ICoMS2024CFP.pdf"
}
TY - CPAPER TI - Evaluating the Bioequivalence of Treatments Using t-ratios Tests T2 - 7th International Conference on Mathematics and Statistics AU - M. Filomena Teodoro AU - Andrade, M. A. P. AU - Teresa A. Oliveira PY - 2024 CY - Amarante, Portugal UR - https://www.icoms.org/ICoMS2024CFP.pdf AB - The main objective of the work is the application of experimental design and some simple tests (t-ratios) in the evaluation of bioequivalence of two treatments. It is performed the assessment of the effectiveness of different treatments administered to two groups of patients: the control group and the test group. The comparison of the control group that received the reference medication with the control group test, which received the drug under study, using a crossover experimental design. It was performed an analysis using t-ratios and considering and inter-subject variability formulation of the probabilistic model, where the specification of tests for detection of carryover and period effects were considered. The application to a practical case consisted in the validation of the hypothesis of the proposed model took place, where the effects carryover and period were not significant when considering usual levels of significance. About the treatments, we could conclude that there was statistical significance to affirm that the studied pharmaceuticals were not bioequivalent. ER -
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