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Adragao, T., Herberth, J., Monier-Faugere, M.-C., Branscum, A. J., Ferreira, A., Frazao, J. M....Malluche, H. H. (2009). Low bone volume - a risk factor for coronary calcifications in hemodialysis patients. Clinical Journal of the American Society of Nephrology. 4 (2), 450-455

T. Adragão et al.,  "Low bone volume - a risk factor for coronary calcifications in hemodialysis patients", in Clinical Journal of the American Society of Nephrology, vol. 4, no. 2, pp. 450-455, 2009

@article{adragão2009_1734881447951,
	author = "Adragao, T. and Herberth, J. and Monier-Faugere, M.-C. and Branscum, A. J. and Ferreira, A. and Frazao, J. M. and Curto, J. D. and Malluche, H. H.",
	title = "Low bone volume - a risk factor for coronary calcifications in hemodialysis patients",
	journal = "Clinical Journal of the American Society of Nephrology",
	year = "2009",
	volume = "4",
	number = "2",
	doi = "10.2215/CJN.01870408",
	pages = "450-455",
	url = "http://cjasn.asnjournals.org/content/4/2/450"
}

TY  - JOUR
TI  - Low bone volume - a risk factor for coronary calcifications in hemodialysis patients
T2  - Clinical Journal of the American Society of Nephrology
VL  - 4
IS  - 2
AU  - Adragao, T.
AU  - Herberth, J.
AU  - Monier-Faugere, M.-C.
AU  - Branscum, A. J.
AU  - Ferreira, A.
AU  - Frazao, J. M.
AU  - Curto, J. D.
AU  - Malluche, H. H.
PY  - 2009
SP  - 450-455
SN  - 1555-9041
DO  - 10.2215/CJN.01870408
UR  - http://cjasn.asnjournals.org/content/4/2/450
AB  - Background and objectives: There is increasing evidence that altered bone metabolism is associated with cardiovascular calcifications in patients with stage 5 chronic kidney disease on hemodialysis (HD). This study was conducted to evaluate the association between bone volume, turnover, and coronary calcifications in HD patients. Design, setting, participants, & measurements: In a cross-sectional study, bone biopsies and multislice computed tomography were performed in 38 HD patients. Bone volume/total volume, activation frequency, and bone formation rate/bone surface were determined by histomorphometry and coronary calcifications were quantified by Agatston scores. Results: Prevalence of low bone turnover was 50% and of low bone volume was 16%. Among the studied traditional cardiovascular risk factors, only age was found to be associated with coronary calcifications. Lower bone volume was a significant risk factor for coronary calcifications during early years of HD, whereas this effect was not observed in patients with dialysis duration >6 yr. Histomorphometric parameters of bone turnover were not associated with coronary calcifications. Conclusions: Low bone volume is associated with increased coronary calcifications in patients on HD.
ER  -