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A publicação pode ser exportada nos seguintes formatos: referência da APA (American Psychological Association), referência do IEEE (Institute of Electrical and Electronics Engineers), BibTeX e RIS.

Exportar Referência (APA)
Sequeira, J., Louçã, J., Mendes, A. M. & Lind, P. G. (2019). Transition from endemic behavior to eradication of malaria due to combined drug therapies: an agent-model approach. Journal of Theoretical Biology. 484
Exportar Referência (IEEE)
J. Sequeira et al.,  "Transition from endemic behavior to eradication of malaria due to combined drug therapies: an agent-model approach", in Journal of Theoretical Biology, vol. 484, 2019
Exportar BibTeX
@article{sequeira2019_1711709231300,
	author = "Sequeira, J. and Louçã, J. and Mendes, A. M. and Lind, P. G.",
	title = "Transition from endemic behavior to eradication of malaria due to combined drug therapies: an agent-model approach",
	journal = "Journal of Theoretical Biology",
	year = "2019",
	volume = "484",
	number = "",
	doi = "10.1016/j.jtbi.2019.110030",
	url = "http://dx.doi.org/10.1016/j.jtbi.2019.110030"
}
Exportar RIS
TY  - JOUR
TI  - Transition from endemic behavior to eradication of malaria due to combined drug therapies: an agent-model approach
T2  - Journal of Theoretical Biology
VL  - 484
AU  - Sequeira, J.
AU  - Louçã, J.
AU  - Mendes, A. M.
AU  - Lind, P. G.
PY  - 2019
SN  - 0022-5193
DO  - 10.1016/j.jtbi.2019.110030
UR  - http://dx.doi.org/10.1016/j.jtbi.2019.110030
AB  - We introduce an agent-based model describing a susceptible-infectious-susceptible (SIS) system of humans and mosquitoes to predict malaria epidemiological scenarios in realistic biological conditions. Emphasis is given to the transition from endemic behavior to eradication of malaria transmission induced by combined drug therapies acting on both the gametocytemia reduction and on the selective mosquito mortality during parasite development in the mosquito. Our mathematical framework enables to uncover the critical values of the parameters characterizing the effect of each drug therapy. Moreover, our results provide quantitative evidence of what was up to now only partially assumed with empirical support: interventions combining gametocytemia reduction through the use of gametocidal drugs, with the selective action of ivermectin during parasite development in the mosquito, may actively promote disease eradication in the long run. In the agent model, the main properties of human-mosquito interactions are implemented as parameters and the model is validated by comparing simulations with real data of malaria incidence collected in the endemic malaria region of Chimoio in Mozambique. Finally, we discuss our findings in light of current drug administration strategies for malaria prevention, which may interfere with human-to-mosquito transmission process.
ER  -