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Cosme, G., Arriaga, P., Rosa, P. J., Mehta, M. A. & Prata, D. (2023). Temporal profile of intranasal oxytocin in the human autonomic nervous system at rest: An electrocardiography and pupillometry study. Journal of Psychopharmacology. 37 (6), 566-576
G. Cosme et al., "Temporal profile of intranasal oxytocin in the human autonomic nervous system at rest: An electrocardiography and pupillometry study", in Journal of Psychopharmacology, vol. 37, no. 6, pp. 566-576, 2023
@article{cosme2023_1734635317656, author = "Cosme, G. and Arriaga, P. and Rosa, P. J. and Mehta, M. A. and Prata, D.", title = "Temporal profile of intranasal oxytocin in the human autonomic nervous system at rest: An electrocardiography and pupillometry study", journal = "Journal of Psychopharmacology", year = "2023", volume = "37", number = "6", doi = "10.1177/02698811231158233", pages = "566-576", url = "https://journals.sagepub.com/doi/10.1177/02698811231158233" }
TY - JOUR TI - Temporal profile of intranasal oxytocin in the human autonomic nervous system at rest: An electrocardiography and pupillometry study T2 - Journal of Psychopharmacology VL - 37 IS - 6 AU - Cosme, G. AU - Arriaga, P. AU - Rosa, P. J. AU - Mehta, M. A. AU - Prata, D. PY - 2023 SP - 566-576 SN - 0269-8811 DO - 10.1177/02698811231158233 UR - https://journals.sagepub.com/doi/10.1177/02698811231158233 AB - Background: Human social behavior is modulated by oxytocin (OT). Intranasal administration of OT (IN-OT) is a noninvasive route shown to elicit changes in the autonomic nervous system (ANS) activity; however, IN-OT’s effect on the temporal profile of ANS activity at rest is yet to be described. Aims: We aimed to describe the temporal profile of IN-OT at six 10-min time windows from 15- to 100-min post-administration in 20 male participants at rest while continuously recording their pupillary in an eyes-open condition and cardiac activity in eyes-open and eyes-closed conditions. Methods: We used a double-blind, placebo-controlled, within-subjects design study where we extracted two proxies of parasympathetic nervous system (PNS) activity: high-frequency heart rate variability (HF-HRV) and pupillary unrest index (PUI); and a proxy of sympathetic nervous system activity: sample entropy of the pupillary unrest. Results: In the eyes-open condition, we found an effect of IN-OT on the proxies of PNS activity: decreased PUI in the three-time windows post-administration spanning 65–100 min, and as an exploratory finding, an increased HF-HRV in the 80–85 min time window. Conclusions: We suggest there is a role of OT in PNS regulation that may be consistent with OT’s currently theorized role in the facilitation of alertness and approach behavior. ER -