How can we measure and monitor the effects of social inequalities in contemporary Portuguese society across regional, national and European scales? International agendas of human and sustainable development accept the premise that to achieve social progress, other dimensions beyond economic growth need to be accounted for. The deep inequalities in Portuguese society threaten the universality of fundamental rights and incite an urgent call for more data, based on technical and scientific knowledge, to understand the relations between inequalities and well-being as well as to frame place-based public policies and interventions. The project aims to develop a system of indicators to improve data availability, visualisation and analysis on the multidimensional relationships between living conditions and well-being in a comparative, intranational and international perspective. The model is based on the OECD framework and will be empirically supported by the European Social Survey as well as other national and international statistical sources. The key findings related to the development and analysis of this data will be considered in the second axis of the project, based on the prospective analysis, by using the Delphi method and place-based case studies. This second stage will involve the mobilization of agents (professionals, technicians and scientists) involved in the organization and implementation of public policies and recruited from the Portuguese Research Network on Public Policies (UMPP). The most valued dimensions in the definition of well-being in different social contexts will be mapped, defining 1) axes of problematic challenges in the relations between inequalities and well-being; 2) sustainable development strategies and place-based priorities from a comparative perspective at national and European levels; and (3) a quantifiable system of indicators and targets that allow the monitoring of the effects of policy action.