The continuous aging of the population has increased health risks, leading to the need for close monitoring of elder citizens and patients. Fortunately, the field of e-Health has been experiencing great progress, although it still faces challenges, since it needs to be applied without compromising the mobility or lifestyle of monitored patients. The challenges facing the development of mobile health monitoring devices are mainly related to power consumption, size, weight, safety, and privacy. Addressing such challenges, WeHope project aims to design the next generation of mobile health monitoring systems, through designing an integrated “in-shoe” optical fiber sensor network, which is able to monitor health conditions by observing physiological parameters in the foot. The WeHope project will design small non-invasive high precision integrated optical fiber sensor network, which is immune to electromagnetic interference and intrinsically electric safe. Such optical fiber sensing network, based on fiber Bragg grating (FBG) technology, will be integrated with a mobile interrogation monitor (FBG-IM) interfacing, and software for remote control of the FBG-IM. The aim of the proposed project is to enhance the life quality of patients; hence WeHope system needs to perform continuous health monitoring without compromising patients’ lifestyle by guaranteeing free mobility. The project thus investigates the provision of ubiquitous energy efficient wireless connectivity with a monitoring application in the cloud. Energy efficiency is key to prolong the lifetime of the system; thus providing longer periods of mobility without the need for recharging. Finally, the project will propose an innovative security scheme to protect sensitive transmitted data, while preserving patient’s privacy, such as location, with an efficient revocation scheme when required (i.e. in emergency situations).