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Marieke van Asselen, Inês Almeida, Filipa Júlio, Januário, C., Bobrowicz-Campos, E., Simões, M....Miguel Castelo-Branco (2012). Implicit Contextual Learning in Prodromal and Early Stage Huntington's Disease Patients. Journal of the International Neuropsychological Society. 18 (4), 689-696

M. V. Asselen et al.,  "Implicit Contextual Learning in Prodromal and Early Stage Huntington's Disease Patients", in Journal of the Int. Neuropsychological Society, vol. 18, no. 4, pp. 689-696, 2012

@article{asselen2012_1715176133328,
	author = "Marieke van Asselen and Inês Almeida and Filipa Júlio and Januário, C. and Bobrowicz-Campos, E. and Simões, M. and Miguel Castelo-Branco",
	title = "Implicit Contextual Learning in Prodromal and Early Stage Huntington's Disease Patients",
	journal = "Journal of the International Neuropsychological Society",
	year = "2012",
	volume = "18",
	number = "4",
	doi = "10.1017/S1355617712000288",
	pages = "689-696"
}

TY  - JOUR
TI  - Implicit Contextual Learning in Prodromal and Early Stage Huntington's Disease Patients
T2  - Journal of the International Neuropsychological Society
VL  - 18
IS  - 4
AU  - Marieke van Asselen
AU  - Inês Almeida
AU  - Filipa Júlio
AU  - Januário, C.
AU  - Bobrowicz-Campos, E.
AU  - Simões, M.
AU  - Miguel Castelo-Branco
PY  - 2012
SP  - 689-696
SN  - 1355-6177
DO  - 10.1017/S1355617712000288
AB  - Huntington’s disease (HD) is a genetic neurodegenerative disorder affecting the basal ganglia. These subcortical structures are particularly important for motor functions, response selection and implicit learning. In the current study, we have assessed prodromal and symptomatic HD participants with an implicit contextual learning task that is not based on motor learning, but on a purely visual implicit learning mechanism. We used an implicit contextual learning task in which subjects need to locate a target among several distractors. In half of the trials, the positions of the distractors and target stimuli were repeated. By memorizing this contextual information, attention can be guided faster to the target stimulus. Nine symptomatic HD participants, 16 prodromal HD participants and 22 control subjects were included. We found that the responses of the control subjects were faster for the repeated trials than for the new trials, indicating that their visual search was facilitated when repeated contextual information was present. In contrast, no difference in response times between the repeated and new trials was found for the symptomatic and prodromal HD participants. The results of the current study indicate that both prodromal and symptomatic HD participants are impaired on an implicit contextual learning task.
ER  -