Scientific journal paper Q1
Geometric optimal control of the generalized Lotka–Volterra model of the intestinal microbiome
Bernard Bonnard (Bonnard, B.); Jérémy Rouot (Rouot, J.); Cristiana J. Silva (Silva, C. J. );
Journal Title
Optimal Control Applications and Methods
Year (definitive publication)
2024
Language
English
Country
United States of America
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Abstract
We introduce the theoretical framework from geometric optimal control for a control system modeled by the generalized Lotka–Volterra equation, motivated by restoring the gut microbiota infected by Clostridium difficile combining antibiotic treatment and fecal injection. We consider both permanent control and sampled-data control related to the medical protocols.
Acknowledgements
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Keywords
Biomathematics and population dynamics,Optimal control in the permanent case,Sampled-data control
  • Mathematics - Natural Sciences
  • Computer and Information Sciences - Natural Sciences
  • Civil Engineering - Engineering and Technology
  • Electrical Engineering, Electronic Engineering, Information Engineering - Engineering and Technology
  • Economics and Business - Social Sciences
Funding Records
Funding Reference Funding Entity
UIDB/04106/2020 Fundação para a Ciência e a Tecnologia
CEECIND/00564/2018 Fundação para a Ciência e a Tecnologia