Português
Ciência-IUL
Publications
Publication Detailed Description
Sex differences in functional connectivity between resting state brain networks in autism spectrum disorder
Journal Title
Journal of Autism and Developmental Disorders
Year (definitive publication)
2022
Language
English
Country
United States of America
More Information
Web of Science®
Scopus
Google Scholar
Abstract
Functional brain connectivity (FBC) has previously been examined in autism spectrum disorder (ASD) between-resting-state networks (RSNs) using a highly sensitive and reproducible hypothesis-free approach. However, results have been inconsistent and sex differences have only recently been taken into consideration using this approach. We estimated main effects of diagnosis and sex and a diagnosis by sex interaction on between-RSNs FBC in 83 ASD (40 females/43 males) and 85 typically developing controls (TC; 43 females/42 males). We found increased connectivity between the default mode (DM) and (a) the executive control networks in ASD (vs. TC); (b) the cerebellum networks in males (vs. females); and (c) female-specific altered connectivity involving visual, language and basal ganglia (BG) networks in ASD—in suggestive compatibility with ASD cognitive and neuroscientific theories.
Acknowledgements
--
Keywords
Functional connectivity,Resting-state networks,Autism spectrum disorder,Independent component analysis,Functional magnetic resonance imaging
Fields of Science and Technology Classification
- Biological Sciences - Natural Sciences
- Clinical Medicine - Medical and Health Sciences
- Health Sciences - Medical and Health Sciences
Funding Records
| Funding Reference | Funding Entity |
|---|---|
| 292/16 | BIAL Foundation |
| LISBOA-01-0145-FEDER-030907 | Fundação para a Ciência e a Tecnologia |
| PD/BD/114460/2016 | Fundação para a Ciência e a Tecnologia |
| UID/MAT/00006/2013 | Fundação para a Ciência e a Tecnologia |
| DSAIPA/DS/0065/2018 | Fundação para a Ciência e a Tecnologia |
| FP7-PEOPLE-2013-CIG-631952 | Comissão Europeia |
| IF/00787/2014 | Fundação para a Ciência e a Tecnologia |
Contributions to the Sustainable Development Goals of the United Nations
With the objective to increase the research activity directed towards the achievement of the United Nations 2030 Sustainable Development Goals, the possibility of associating scientific publications with the Sustainable Development Goals is now available in Ciência-IUL. These are the Sustainable Development Goals identified by the author(s) for this publication. For more detailed information on the Sustainable Development Goals, click here.
