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Publication Detailed Description
Institutionalization and indiscriminate social behavior: differential-susceptibility versus diathesis-stress models for the 5-HTTLPR and BDNF genotypes
Journal Title
Physiology and Behavior
Year (definitive publication)
2015
Language
English
Country
Netherlands
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Abstract
Institutionalization adversely impacts children’s emotional functioning, proving related to attachment disorders, perhaps most notably that involving indiscriminate behavior, the subject of this report. In seeking to extend work in this area, this research on gene X environment (GXE) interplay investigated whether the serotonin transporter (5-HTTLPR) and val66met Brain–Derived Neurotrophic Factor (BDNF) polymorphisms moderated the effect of institutional care on indiscriminate behavior in preschoolers. Eighty-five institutionalized and 135 home-reared Portuguese children were assessed using Disturbances of Attachment Interview (DAI). GXE results indicated that s/s homozygotes of the 5-HTTLPR gene displayed significantly higher levels of indiscriminate behavior than all other children if institutionalized, something not true of such children when family reared. These findings proved consistent with the diathesis-stress rather than differential-susceptibility model of person-X-environment interaction. BDNF proved unrelated to indiscriminate behavior. Results are discussed in relation to previous work on this subject of indiscriminate behavior, institutionalization and GXE interaction.
Acknowledgements
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Keywords
Institutionalization,Indiscriminate behavior,BDNF,5-HTTLPR,Diathesis-stress,Differential susceptibility
Fields of Science and Technology Classification
- Psychology - Social Sciences
Funding Records
| Funding Reference | Funding Entity |
|---|---|
| PTDC/PSI-PCL/101506/2008 | Fundação para a Ciência e a Tecnologia |
| PTDC/PSI-PCL/116897/2010 | Fundação para a Ciência e a Tecnologia |
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