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Publication Detailed Description
Discovery of novel plant peptides as strong inhibitors of metalloprotein-ases
Journal Title
Protein and Peptide Letters
Year (definitive publication)
2009
Language
English
Country
United Arab Emirates
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Abstract
Five novel metalloproteinase protein inhibitors (MPIs) with molecular mass between 5.6 and 8.9 kDa and acid/neutral pI were detected in lupin seeds and exhibited strong inhibitory activities against thermolysin and/or gelatinase B. These novel peptides constitute not only the first MPIs described in plants but also the first plant peptides with inhibitory activity against a matrixin.
Acknowledgements
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Keywords
PROTEIN INHIBITORS,MATRIX METALLOPROTEINASES,PROTEOLYTIC-ENZYMES,MASS-SPECTROMETRY,LUPINUS-ALBUS,SNAKE-VENOM
Fields of Science and Technology Classification
- Biological Sciences - Natural Sciences
- Clinical Medicine - Medical and Health Sciences
- Other Medical Sciences - Medical and Health Sciences
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